HIV PROTEASE INHIBITORS DISRUPT LIPID METABOLISM BY ACTIVATING ENDOPLASMIC RETICULUM STRESS AND INHIBITING AUTOPHAGY ACTIVITY IN ADIPOCYTES.

HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytes.

BackgroundHIV protease inhibitors (PI) are Swim Panty core components of Highly Active Antiretroviral Therapy (HAART), the most effective treatment for HIV infection currently available.However, HIV PIs have now been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease and metabolic syndrome.Our previous

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Assessing Multiplex Tiling PCR Sequencing Approaches for Detecting Genomic Variants of SARS-CoV-2 in Municipal Wastewater

Monitoring the genomic characteristics of the SARS-CoV-2 virus circulating in a population can shed important insights into epidemiological aspects NFL Boxes of the COVID-19 outbreak.Sequencing every clinical patient sample in a highly populous area is a difficult feat, and thus sequencing SARS-CoV-2 RNA in municipal wastewater offers great promise

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Towards Standardized, Safe, and Efficacious Screening Approaches to Patients with Lower Extremity Peripheral Arterial Disease in the Setting of Lower Extremity Arthroplasty

Introduction: Peripheral arterial disease (PAD) impedes the ability to recover from lower extremity arthroplasties (LEA) while simultaneously increasing risks of peri- and postoperative complications, morbidity, and mortality.Despite the known risks that PAD presents, there are Simpsons currently no standards outlining how practitioners should scre

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